What is Naturalized Folate?
Naturalized folate is also known as calcium 6S-5-Methyltetrahydrofolate. It is the main form of folic acid present in the body and the main metabolically active product of synthetic folic acid in the body. Its properties are close to natural folic acid, and its stability and bioavailability are better than that of natural folic acid.
Risks associated with unmetabolized folic acid
The main form of folic acid supplementation currently available is synthetic folic acid, but excessive supplementation can increase the risk of disease in oneself and one's offspring. Oral doses of synthetic folic acid above 200ug/d saturate the metabolic capacity of the liver and result in the presence of unmetabolized folic acid (UMFA) in the blood, the deposition of which in the bloodstream can lead to potentially toxic effects.
Naturalized folate, on the other hand, is better for people who are not genetically predisposed to folate metabolism and can be absorbed directly, so there is no risk of unmetabolized folate accumulation.
Benefits of naturalized folate
- Corrects impaired folate metabolism
- Effective in treating adverse pregnancies
- Rapidly boosts folate levels in the body and reduces the risk of unmetabolized folate
- Reduces homocysteine levels
- Preventive treatment of cardiovascular disease and may have neuroprotective effects in stroke patients
- Supports mental health and provides new ideas for improving depressive symptoms
- Boosts immunity against external pathogens
Advantages of naturalized folate
- Highly pure, active acid content ≥90.0 per cent
- Good solubility good, high bioavailability
- Good stability to ensure the quality of finished product
- Practically non-toxic, ultimate safety
- Removal of harmful impurities and control of heavy metal content
Differences between synthetic folic acid and active folate
| Biological property |
Synthetic folic acid |
Active folate |
| Impact on VB12 utilization |
Masking B12 deficiency predisposes to neurological damage |
Does not mask B12 deficiency |
| Access to the brain. |
Cannot cross the blood-brain barrier |
Can cross the blood-brain barrier |
| Absorption site |
Absorbed in the liver |
Absorbed through the intestines |
| Assimilate and utilize |
Needs to be converted in the body by a multi-step enzymatic reaction before it can be utilized |
Does not require the action of converting enzymes and can be absorbed and utilized directly. |
| Folate metabolic disorders |
Affected |
Unaffected |
| Source |
Easy to obtain |
Easy to obtain |
| Chemical stabilities |
Stabilize |
Crystalline stability |
| Allergies and side effects |
There have been reports of itchy skin, allergies, and even miscarriages. |
/ |
| Antioxidant properties |
/ |
Strong |
Differences between active folate and naturalized folate
| Biological property |
Active folate |
Naturalized folate |
| Biological raw materials |
Heavy metal |
Use |
Non-use |
| Genotoxic raw materials |
Use |
Non-use |
| Main quality indicators |
Related substances |
JK12A≤1.0% |
JK12A≤0.1% |
| 5-Methyltetrahydropteric acid≤0.5% |
5-Methyltetrahydropteric acid: Not to be detected |
| Total impurities≤ 2.5% |
Total impurities≤ 0.5% |
| D-isomer |
D-5-methylhydrofolate≤1.0% |
D-5-methylhydrofolate≤0.1% |
Baoding Faithful Industry Co., Ltd. was established in 2005 and is located in the National High Tech Industrial Science and Technology Park of Baoding City, Hebei Province. It specializes in researching, producing, and selling raw materials for health products. Its main products include sodium hyaluronate, collagen, trypsin, gastric enzymes, and plant extracts. Our products are exported to over 20 countries, including the Americas, Europe, and Asia. We have extensive markets and research centers in the United States, Germany, Japan, and other places and a vast database of cutting-edge skin biology that accurately captures global trends. The laboratory has senior engineers and high-end experimental equipment, pursuing ultimate scientificity and safety and meeting consumers' high requirements for quality of life. We have established a comprehensive service system from quality control and sales to after-sales service and have passed the ISO9001 quality management system. We will provide new and old cosmetics customers with higher quality products, higher quality, more complete, and more thoughtful services.
Our Advantage
We observe the highest standards of active pharmaceutical ingredients quality protection, borne out by periodic audits conducted by customers and, mainly, by state authorities. The active substances we manufacture are of a constant quality guaranteed by trained QA/QC officers. We are continually introducing innovative outputs from a large base of R&D experts into the manufacture of our products in order to be able to deliver the purest, safest substances to our customers.
1. Fast response and professional service.
Your inquiry will be replied to within 24 hours, including holidays.
2. Best quality in your requirement.
3. Competitive price in China market
4. Mature technical support
5. Rich export experience
We have nearly 20 years of export experience and can help you choose the safest transportation method. We will prepare a complete set of customs clearance documents and send them along with the goods.
6. After-sales service
Tracking your goods till you receive them. If there are any problems during the shipment, we will contact the shipping company and solve them in time.
We're responsible for the product quality.
We'll provide professional technical information and service to all of our clients.
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