What is Undenatured Collagen Type II?
Undenatured Collagen Type II is a natural, safe, and potent food ingredient containing Undenatured Collagen Type II to support joint comfort and flexibility during daily activities. This active formula has been proven safe and effective by two human trials. Non-modified collagen type II is a triple-weft cable structure consisting of multiple polypeptide chains linked together, which is not easily broken down by stomach acid and pepsin. Non-denatured collagen type II is extracted under low temperature, freeze-dried and pulverized, preserving the three-stranded helical structure of collagen type II, thus retaining its activity and physiological function.
Modulation of the immune system
When Undenatured Collagen Type II enters the digestive system through oral administration, it interacts with antigen-presenting cells (e.g., dendritic cells) of the immune system in the intestinal-associated lymphoid tissues in the small intestine. This process is called oral tolerance. First, dendritic cells recognize and take up Undenatured Collagen Type II, which they then present to T cells. The T cells then differentiate into regulatory T cells (Tregs) after receiving antigen presentation. Undenatured Collagen Type II generates induced regulatory T cells, which in turn down-regulate the inflammatory response in the joints, inhibit the production of pro-inflammatory cytokines, help to remove damaged cartilage, slow down the immune system's attack on your own cartilage, and promote the production of more healthy cartilage tissue in the joints.
Relieves arthritis pain
Reduces inflammation and cartilage degeneration. Undenatured Collagen Type II protects cartilage by reducing the inflammatory response in joints. Undenatured Collagen Type II protects the cartilage matrix by reducing the activity of inflammation-induced cartilage-degrading enzymes such as matrix metalloproteinases. Slows cartilage destruction by modulating the immune response and reducing immune system attack on articular cartilage. As a result of reduced inflammation and cartilage protection, joint pain and stiffness are relieved, helping to improve overall athleticism and joint range of motion.
Improve Bone Density
Undenatured Collagen Type II can help mineralize bone and also reduce the production of inflammatory cellular hormones, increasing bone density by reducing oxidative stress, which is positively helpful in improving bone mineral density.
Safety: Undenatured Collagen Type II is usually extracted from the cartilage of chicken breast bone, a natural source, and is properly processed to make dietary supplements with a high degree of safety.
Non-denatured: Undenatured Collagen Type II maintains its natural triple helix structure and has not been subjected to high temperature or chemical treatment, unlike denatured collagen which loses its original function and structural integrity.
Homology: Chicken type II collagen is more homologous to the type II collagen in the joints of RA patients than that of bovine, porcine and murine sources.
Similarity: Chicken and human collagen type II have similar molecular weights and 52% protein sequence similarity, with 37% complete sequence overlap.
Low dosage: The dosage of Undenatured Collagen Type II is only 40mg/day, whereas aminoglycans and chondroitin usually require 1500-2700mg/day.
Osteoarthritis.It can relieve symptoms of osteoarthritis and improve joint function.
Rheumatoid arthritis.It can reduce the pain caused by rheumatoid arthritis by regulating the immune system.
Athletes and fitness enthusiasts.Helps to protect joints and prevent joint injuries
Middle-aged and elderly people.Can help prevent joint degeneration and keep joints healthy and flexible.
Autoimmune diseases.Regulates the immune system through oral tolerance mechanism
Joint health dietary supplements.Added to various joint health products to help people maintain joint health
Recovering patients.Can help accelerate recovery and reduce post-operative pain and inflammation
| Difference between Undenatured Collagen Type II and Hydrolyzed Collagen Type II |
| |
Undenatured Collagen Type II |
Hydrolyzed Collagen Type II |
| Sorce: |
100% Chicken Cartilage |
Cartilage |
| Manufacturing process: |
Low temperature patent extraction technology |
Enzymatic hydrolysis |
| Molecular structure: |
The structure of triple helix is complete, and its activity and absorption are better |
The molecular structure is destroyed
|
| Principle of efficacy: |
Immune tolerance promotes cartilage repair and regeneration
|
Provide the nutrition needed by cartilage tissue |
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