Faithful Supply High Quality Cosmetic Raw Materials CAS 59870-68-7 Glabridin

• Customization: Available
• Certification: RoHS, BRC, ISO, FDA, HACCP
• Extraction Process: Chemical
• State: Powder
• Extract Source: Licorice
• Trademark: FAISFOR
• Origin: China

Product Description

What is Glabridin?

Glabridin, also known as Glycyrrhizic Flavone, is a kind of isoflavone. It is extracted from the dried rhizome of Glycyrrhiza glabra L. Glabridin is one of the main flavonoids in Glycyrrhiza glabra (accounting for 11%). Faithful develops five different Glabridin specifications: Glabridin B, Glabridin C, Glabridin FHC01, Glabridin FHC07, and Glabridin Solution.

Glabridin Specifications
 

Product Name	Efficacy and composition	Instructions	Description	Assay
Glabridin B	Glabridin is a natural whitening agent extracted from specific varieties of licorice. It has strong antibacterial properties and prevents UV-induced inflammation, pigmentation, and rough skin. It can remove superoxide ions and inhibit hemolysis caused by hydrogen peroxide. It can inhibit the activity of tyrosinase but also can inhibit the activity of dopachrome interconversion and DHICA oxidase. lt is a fast, high-efficiency, green-whitening cosmetic additive with similarity to SOD (superoxide dismutase). The ability to scavenge oxygen free radicals also has the ability to resist oxygen radicals, similar to vitamin E.	The product is dissolved at room temperature with 1,3-butanediol, dissolved in the ratio of 1:100, and then added to the cosmetic formula as needed.	Yellowish brown to reddish brown powder.	>40.0%
Glabridin C	Glabridin is a natural whitening agent extracted from specific varieties of licorice. It has strong antibacterial properties and prevents UV-induced inflammation, pigmentation, and rough skin. It can remove superoxide ions and inhibit hemolysis caused by hydrogen peroxide. It can inhibit the activity of tyrosinase but also can inhibit the activity of dopachrome interconversion and DHICA oxidase. lt is a fast, high-efficiency, green-whitening cosmetic additive with similarity to SOD (superoxide dismutase). The ability to scavenge oxygen free radicals also has the ability to resist oxygen radicals, similar to vitamin E.	The product is dissolved at room temperature with 1,3-butanediol, dissolved in the ratio of 1:100, and then added to the cosmetic formula as needed.	Almost White Powder	>90.0%
Glabridin FHC01	Glabridin is a natural whitening agent extracted from specific varieties of licorice. It has strong antibacterial properties and prevents UV-induced inflammation, pigmentation, and rough skin. It can remove superoxide ions and inhibit hemolysis caused by hydrogen peroxide. It can inhibit the activity of tyrosinase but also can inhibit the activity of dopachrome interconversion and DHICA oxidase. lt is a fast, high-efficiency, green-whitening cosmetic additive with similarity to SOD (superoxide dismutase). The ability to scavenge oxygen free radicals also has the ability to resist oxygen radicals, similar to vitamin E.	The product is dissolved at room temperature with 1,3-butanediol, dissolved in the ratio of 1:100, and then added to the cosmetic formula as needed.	Almost White Powder	37.0%~43.0%
Glabridin FHC07	Glabridin is a natural whitening agent extracted from specific varieties of licorice. It has strong antibacterial properties and prevents UV-induced inflammation, pigmentation, and rough skin. It can remove superoxide ions and inhibit hemolysis caused by hydrogen peroxide. It can inhibit the activity of tyrosinase but also can inhibit the activity of dopachrome interconversion and DHICA oxidase. lt is a fast, high-efficiency, green-whitening cosmetic additive with similarity to SOD (superoxide dismutase). The ability to scavenge oxygen free radicals also has the ability to resist oxygen radicals, similar to vitamin E.	The product is dissolved at room temperature with 1,3-butanediol, dissolved in the ratio of 1:100, and then added to the cosmetic formula as needed.	Almost White Powder	37.0%~43.0%
Glabridin Solution	Glabridin is a natural whitening agent extracted from specific varieties of licorice. It has strong antibacterial properties and prevents UV-induced inflammation, pigmentation, and rough skin. It can remove superoxide ions and inhibit hemolysis caused by hydrogen peroxide. It can inhibit the activity of tyrosinase but also can inhibit the activity of dopachrome interconversion and DHICA oxidase. lt is a fast, high-efficiency, green-whitening cosmetic additive with similarity to SOD (superoxide dismutase). The ability to scavenge oxygen free radicals also has the ability to resist oxygen radicals, similar to vitamin E. Glabridin is easily soluble in organic solvents, but its water solubility is poor. In order to meet the application in water-based cosmetics, we used hydroxypropyl cyclodextrin to embed glabridin, which effectively increased the solubility of the product in water; at the same time, the stability of the embedded glabridin was greatly enhanced, and the shelf life of the product was prolonged.	Add any proportion of this product to the aqueous phase.	Colorless transparent liquid	1.80%~2.20%

Glabridin Benefits

Skin whitening
As a natural whitening ingredient, the skin-whitening mechanism of Glabridin mainly includes (1) inhibiting tyrosinase activity, (2) inhibiting the activity of dopachrome tautomerase (TRP-2), (3) inhibiting the activity of DHICA oxidase; (4) exerting the function of endothelin antagonist; (5) increasing the total antioxidant capacity of the skin; (6) effectively scavenging oxygen free radicals and its chain reaction. Moreover, through these synergistic effects, it effectively prevents the polymerization of 5,6-dihydroxyindole (DHI) and the production of dopachrome. Thereby, Glabridin can disturb and hinder the formation and transport of melanin, and then it inhibits and reduces pigmentation so as to achieve a whitening skin effect.

Anti-inflammatory and antibacterial
The anti-inflammatory effect of Glabridin is related to its anti-oxidative activity of scavenging reactive oxygen. Glabridin can inhibit the production of NO in macrophages and the expression of inducible NO synthase. Then it can prevent the development of inflammation. Also Glabridin can inhibit the activity of staphylococcus aureus and candida albicans. It has a strong antibacterial effect, and can be used for the treatment of acne.

Antioxidant
Glabridin has shown strong anti-free radical oxidation in the cytochrome oxidation system. It can significantly inhibit the free radicals generated in the body's metabolism. Then, it prevents the oxidation-sensitive bio-macromolecules (LDL, LDL, DNA) and cell walls from being oxidized and damaged by free radicals. As an antioxidant, Glabridin can also inhibit the production of reactive oxygen species and activation of p53; it regulates the cleavage of BCL-2 and poly ADP ribose polymerase. It can fight against oxygenated DNA fragments of keratinocytes induced by UV; then, it prevents sun-induced skin aging.

Sunscreen
The conjugate property in the molecular structure of licorice flavonoids assures that Glabridin is characterized by strong absorption of both ultraviolet and visible light. Therefore, the sunscreen mechanism of Glabridin has the highest absorption peak for ultraviolet rays. It effectively blocks ultraviolet rays from the skin surface after being applied to the skin. Furthermore, it also works by absorbing unstable molecules of high-energy ultraviolet rays. Then, it converts the ultraviolet rays that damage the skin into harmless, low-energy, and non-damaging ones.

Glabridin Applications
 

Glabridin is mainly used in whitening and freckle-removing cosmetics, such as emulsion, toner, essence, facial mask, cream, etc.

Glabridin Production Process
 

Glabridin Product Certificate


China Compliant
EU Compliant
Japan Compliant
REACH Registered
US Compliant
Allergen Free
GMO-Free
Halal
Not Tested on Animals

Certificate of Analysis