Customization: | Available |
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CAS No.: | 9012-76-4 |
Packaging Material: | Plastic |
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Chitosan is derived from chitin, a fibrous compound found mainly on the hard outer skeletons of crustaceans and in the cell walls of some fungi. An enzymatic reaction produces chitosan - a more suitable form for supplements. Chitosan is biodegradable and has been used in the development of antimicrobial films for food packaging. It's also approved for use in wound dressings due to its ability to form a gel. Chitosan is now being studied for use in medications and tissue engineering. Most commercially available chitosan is derived from crabs and other shellfish.
Chitosan supplements are often touted as fat-blockers.Chitosan is said to work by turning into a gel in the stomach. Some claim that when that gel moves from the stomach to the intestines, it binds to fat and cholesterol.
The idea is that chitosan may support weight loss and lower cholesterol by eliminating fat and cholesterol from the body instead of allowing the body to absorb them.
That's why the labels on chitosan supplements direct consumers to take it just before meals. Otherwise, there would be nothing in the gut for it to bind to.
However, current evidence doesn't support these claims.
Clinical trials in the early 2000s found that chitosan did not significantly increase fat excretion in stool. Although chitosan is a fiber and could very well form a gel in the body, there's no indication that it actually traps fat.
Soft tissue injury refers to laceration and contusion of the skin, subcutaneous tissue, and muscle caused by an external force, bleeding, and local swelling. Wound healing depends on the nature and degree of tissue defects, whereas age, nutritional status, and underlying diseases are systemic factors affecting wound healing. Promoting wound healing and reducing scar formation are urgent medical problems to be solved for patients with wounds and defects in body function. The antibacterial properties of chitosan and its ability to promote tissue regeneration have increased its usage in wound dressings combined with different materials, which have the overall effect of promoting wound healing.
Impregnating chitosan hydrogels with silver nanoparticles can significantly improve antibacterial and antioxidant properties and enhance wound healing in vivo. The anti-biofilm formation ability of chitosan-immobilized ficin can inhibit S. aureus infections and promote the formation of smoother epithelial tissue. Vaccinin-chitosan nanoparticles can promote vascular tissue production by upregulating IL-1β and PDGF-BB, thereby highlighting its potential in wound healing. The curcumin-loaded chitosan membranes can effectively inhibit bacterial pathogens in wounds by increasing the formation of fibrous connective tissue. Additionally, they have an obvious healing effect on wounds resulting from second-degree burns. A study reports that macrophage dysfunction can lead to chronic inflammation and inhibit diabetic wound healing. Chitosan sulfate can improve macrophage function by inducing the polarization of M1 macrophages to M2 macrophages and promoting the production of anti-inflammatory factors, thus effectively promoting diabetic wound healing. Chitosan has antibacterial, antioxidant, and immunomodulatory effects that can prevent the infection of wounds and promote healing through soft.
Skin injuries or necrosis caused by crush, burn, or cut injuries are medical problems warranting urgent care. Common treatment methods include autogenous skin transplantation and free or pedicled skin-flap transplantation, which can cause problems, such as graft tissue necrosis, scar contracture, and poor cosmetic appearance. The tissue-repair function of chitosan provides a novel solution for skin reconstruction. Hydrogels synthesized from chitosan and cellulose can accelerate epithelial tissue formation on wounds and mimic skin structure, induce skin regeneration, and can be loaded with antibacterial agents to prevent wound infections. Lithium chloride-loaded chitosan hydrogels can significantly reduce wound inflammation, promote angiogenesis, and accelerate epithelial regeneration, thereby showing a potential dressing for skin regeneration. Chitosan wound dressings containing exosomes derived from overexpressed miRNA-126 synovial mesenchymal stem cells can promote epithelium formation, angiogenesis, and collagen maturation in diabetic rats. Chitosan can promote skin regeneration by promoting angiogenesis and epithelium formation.