What is Sodium hyaluronate?
Sodium hyaluronate is a salt form of hyaluronic acid, a naturally occurring substance in the body. It is a linear polysaccharide, and the structure consists of repetitive disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine bound by β(1→3) and β(1→4) glycosidic bonds. It can be obtained by extracting from cockscomb or through microorganism fermentation. Sodium hyaluronate is derived from hyaluronic acid, a high molecular weight biopolymer. When the acid is neutralized, it results in its salt form, sodium hyaluronate. It is highly soluble in water, forming a viscous and clear solution. Its molecular weight ranges from tens of thousands to multi-million, and its main physiological functions are moisture, lubrication, and osmoregulation.
Product Name: Sodium hyaluronate
CAS: 9067-32-7
EINECS: 618-620-0
Formula: (C14H20NNaO11)n
Synonym: Hyaluronic Acid, Hyaluronan, HA, Hyaluronic acid sodium salt, HA Sodium, Hyaluronate Sodium
Source: Microbial fermentation
Features: Hyaluronic acid has the physical properties of high viscosity, outstanding moisture-keeping ability, lubricating effect, etc., and physiological functions of wound healing, protection against infection, collagen fiber biosynthesis, etc.
Hyaluronic acid has high solubility.
Hyaluronic acid is known to be degraded by heat, enzymes, etc., but can be stabilized by crosslinked structure.
What Can We Supply?
| Grade |
Type |
| Food Grade Sodium Hyaluronate |
Food Grade Sodium Hyaluronate |
| Cosmetic Grade Sodium Hyaluronate |
Cosmetic Grade Sodium Hyaluronate |
| Oligo Sodium Hyaluronate |
| Sodium Hyaluronate Solution |
| Multiple Sodium Hyaluronate Solution |
| Cationic Hyaluronic Acid |
| Oil-dispersed Sodium Hyaluronate |
| Acetylated Sodium Hyaluronate |
| Sodium Hyaluronate Fermentation Filtrate |
| Fullerene Sodium Hyaluronate Solution |
| Eye Drop Grade Sodium Hyaluronate |
Eye Drop Grade Sodium Hyaluronate |
| Injection Grade Sodium Hyaluronate |
Injection Grade Sodium Hyaluronate |
| N-series Sodium Hyaluronate |
N-series Sodium Hyaluronate |
| Pet Grade Sodium Hyaluronate |
Pet Grade Sodium Hyaluronate |
It's important to note that these grades of sodium hyaluronate are not interchangeable, and a product intended for one use may not be suitable for another use. For example, food-grade sodium hyaluronate should not be used in medical or cosmetic applications, as it may not meet the necessary purity or quality standards. Similarly, medical-grade sodium hyaluronate should not be used in food products, as it may be unsafe for ingestion.
If you are interested, please feel free to contact us for more information.
The Application of Sodium Hyaluronate
Food Grade Sodium Hyaluronate
1. Food additive
2. Dietary supplements
Cosmetic Grade Sodium Hyaluronate
1. Skin care products: creams, lotions, lotions, essences, gels, masks, etc
2. Cleaning products: facial cleanser, shower gel, etc
3. Hair products: shampoo, conditioner, hair restorer, hair spray, etc
Eye Drop Grade Sodium Hyaluronate
1. Eye drops, eye lotions, contact lens solutions, medical lubricants, etc
2. Topical preparations ( formulations of gel, film, etc.)
3. Eye drops, cell culture, etc
4. Oral pharmaceutical preparations
Injection Grade Sodium Hyaluronate
1. Ophthalmic Viscosurgical Devices(OVD)
2. Intra-articular injections
3. Anti-adhesive products, dermal filler, scaffold materials in tissue engineering, etc
N-series Sodium Hyaluronate
1. Beauty injection
Pet Grade Sodium Hyaluronate
1.Pet food additives
If you are interested, please feel free to contact us for more information.
The Function of Sodium Hyaluronate
1. Regulate osmotic pressure, maintain tissue morphology, nourish cranial nerves
2.Protect gastric mucosa, lubricate lumen
3. Supplement HA in the body, maintain normal body function, and improve immunity
4. Promote cartilage repair, inhibit inflammation, and relieve soreness
5. Replenish eyeball moisture and relieve dry, astringent, and itchy eyes
6. Replenish skin moisture, enhance skin elasticity, and reduce wrinkles
7. A dense biological moisturizing film is formed on the skin surface, which is long-lasting moisturizing and anti-PM2.5
8. Good moisturizing and lubricating properties, slow-release, stable emulsification
9. Repair damaged and early-aged skin; water and soften the stratum corneum, lasting moisturizing, soft skin; increase skin elasticity and delay skin aging; promote the proliferation and differentiation of epidermal cells, scavenge oxygen free radicals
10. Transdermal absorption, deep moisturizing. Anti-aging, repair after sun
11. Lubricating, moisturizing, improving the efficacy of drugs, relieving dry eye syndrome, and promoting healing of corneal and conjunctival injury
12. Wound Healing
13. Drug or cell carrier/matrix
14. Repairing damaged mucous membranes or cartilage etc
15. Viscoelasticity, protecting corneal endothelium
16. Lubricating, viscoelasticity, repairing damaged cartilage, inhibiting inflammation, pain relief, etc
17. Good biocompatibility and bio-degradability of HA and its derivatives
If you are interested, please feel free to contact us for more information.
1. Non-GMO
2. All research products are derived from pharmaceutical GMP batches, ensuring easy translation from pre-clinical programs into clinical trials and commercial manufacturing
3. Non-animal-sourced products produced through microbial fermentation
4. Stability studies on a variety of commercial products have demonstrated compliance with client's stability requirements
5. Large batch sizes
6. Well-designed purification processes
7. Access SDS
Different molecular weight segments
| High molecular weight sodium hyaluronate |
>1.6 million Da |
| Medium molecular weight sodium hyaluronate |
0.2million~1.6million Da |
| Low molecular weight sodium hyaluronate |
0.01million~0.2million Da |
| Ultra low molecular weight sodium hyaluronate |
<10000 Da |
Analysis sheet
| Product |
Sodium hyaluronate |
Grade |
HA-EP1.8 |
| Batch No. |
22051311 |
Batch size |
6.370kg |
| Intrinsic viscosity |
1.6~2.2 m^3/kg |
Production date |
2022.05.14 |
| Standard |
Ph. Eur.10.0 |
Expiry date |
2025.05.14 |
| Items |
Acceptance criteria |
Results |
| Characters |
White or almost white powder or fibrous aggregate |
White powder |
Identification
- Infrared absorption
- Reaction of sodium
|
Consistent with the reference substance spectrum of sodium hyaluronate
Positive
|
Complies
Positive |
| Appearance of solution |
Clear
A600nm≤0.01 |
Clear
0.00 |
| pH |
5.0~8.5 |
6.2 |
| Intrinsic viscosity |
1.6~2.2 m^3/kg |
1.85 m^3/kg |
| Nucleic acids |
A260nm≤0.5 |
0.01 |
| Protein |
≤0.1% |
<0.0004% |
| Chlorides |
≤0.5% |
<0.5% |
| Iron |
≤30 ppm |
2ppm |
| Loss on drying |
≤15.0% |
9.2% |
Microbial contamination
(TAMC) |
≤100 cfu/g |
<20 cfu/g |
| Bacterial Endotoxins |
<0.05 IU/mg |
<0.05 IU/mg |
| Residual solvents (Ethanol) |
≤5000 ppm |
<186 ppm |
| Residual solvents (Methanol) |
≤300 ppm |
<32 ppm |
| Formaldehyde |
≤50 ppm |
<5.2 ppm |
| Assay |
95.0%~105.0%(dried substance) |
100.2% |
The production process of each of our sodium hyaluronate products is different. The following takes Oligo Sodium Hyaluronate as an example to introduce our rigorous production process. If you also want to know the production process of other hyaluronic acid products, please feel free to contact us anytime.
The production process of Oligo Sodium Hyaluronate
Semi-finished product of sodium hyaluronate
Dissolving
Enzymatic hydrolysis
Enzyme inactivation
Filtration
Precipitation
Centrifugation
Drying
Sieving and crushing
Packing
Metal detection(CCP)
Storage
GMP certificate
CoS certificate
DMF submitted to FDA, USA
ISO
ECOCERT
KOSHER
HALAL
REACH
COSMOS
Packing & Shipping & Payment
| Storage |
Stockpiled at a ventilated place, avoiding rain, moisture, and insolation. Please handle with care to prevent bag damage and store away from toxic substances. |
| Packing |
Inner packaging: 1kg/aluminum foil bag
Outer packaging: 10kg/square bucket or 20kg/square bucket |
| Shipping time by express |
5-7 days by TNT, DHL, FEDEX, UPS, EMS |
| Shipping time by air |
7-10 days |
| Shipping time by sea |
* South America: around 40-60 days
* Southeast Asia: around 10-25 days
* Africa: around 40 days
* Europe: around 35 days |
| Transportation |
Door to Door |
Our Service
Baoding Faithful Industry Co., Ltd. was established in 2005 and is located in the National High Tech Industrial Science and Technology Park of Baoding City, Hebei Province. It specializes in researching, producing, and selling raw materials for health products. Its main products include sodium hyaluronate, collagen, trypsin, gastric enzymes, and plant extracts. Our products are exported to over 20 countries, including the Americas, Europe, and Asia. We have extensive markets and research centers in the United States, Germany, Japan, and other places and a vast database of cutting-edge skin biology that accurately captures global trends. The laboratory has senior engineers and high-end experimental equipment, pursuing ultimate scientificity and safety and meeting consumers' high requirements for quality of life. We have established a comprehensive service system from quality control and sales to after-sales service and have passed the ISO9001 quality management system. We will provide new and old cosmetics customers with higher quality products, higher quality, more complete, and more thoughtful services.
Our Advantage
We observe the highest standards of active pharmaceutical ingredients quality protection, borne out by periodic audits conducted by customers and, mainly, by state authorities. The active substances we manufacture are of a constant quality guaranteed by trained QA/QC officers. We are continually introducing innovative outputs from a large base of R&D experts into the manufacture of our products in order to be able to deliver the purest, safest substances to our customers.
1. Fast response and professional service.
Your inquiry will be replied to within 24 hours, including holidays.
2. Best quality in your requirement.
3. Competitive price in China market
4. Mature technical support
5. Rich export experience
We have nearly 20 years of export experience and can help you choose the safest transportation method. We will prepare a complete set of customs clearance documents and send them along with the goods.
6. After-sales service
Tracking your goods till you receive them. If there are any problems during the shipment, we will contact the shipping company and solve them in time.
We're responsible for the product quality.
We'll provide professional technical information and service to all of our clients.
FAQ
Q1. Although 80,000 molecular weight Hyaluronic acid has excellent absorption and penetration of the skin but is not thick enough, 1.2 million molecular weight Hyaluronic acid, although wide but not good skin penetration, thick acid, the most cost-effective way is what?
A1: Suggest high molecular weight and low molecular weight mix achieve both dense and can be very good skin penetration; absorption effect is good.
Q2. The difference between different molecular weights
A2: High molecular weight HA is more stable and suitable for some cream-type cosmetics. Hyaluronic acid of moderate molecular weight is more accessible to absorb than that of high molecular weight, so it is suitable for use in thin cream. Low molecular weight Hyaluronic acid is easily absorbed by the skin and is suitable to be added to hydrating masks and hydrating products.
Q3. What's the difference between Sodium hyaluronate and hyaluronic acid?
A3: Hyaluronic acid exists in human and animal organs and tissues. Human beings use modern scientific production technology, such as biological fermentation methods, to produce hyaluronic acid in the form of sodium salt, which is used by human beings.
Q4. What is our minimum order quantity?
A4: The minimum order quantity for food grade and cosmetic grade is 100g, and the minimum order quantity for the pharmaceutical grade is 1g.
Q5. Is there a discount?
A5: Different quantity has different discounts.
Q6. How do you start placing orders or making payments?
A6: You can send us your purchase order (if your company has one) or send a simple confirmation via email or trade manager. We will send you a formal invoice with our bank details for confirmation, and you can make the payment accordingly.
Q7. How do you ensure the quality of the product?
A7: Our company has multiple high-end imported devices, including high-performance liquid chromatography, gas chromatography, and atomic absorption spectroscopy. We have established a comprehensive quality management system following GMP requirements and strictly controlling the quality. We also accept testing by third-party testing agencies such as SGS and Eurofins. In addition, you can obtain samples and send us your product specifications and requirements, and we will manufacture the product according to your needs.
Q8. Can I get some samples?
A8: Yes, we can supply the free sample, but the shipping cost will be paid by our customers.
Q9.How do you confirm product quality before placing an order?
A9: You can send us your product specifications and requirements, and we will produce the products according to your requirements. You can get free samples of some products, you just need to pay the shipping cost or arrange express delivery to us and get the sample.
Q10. How do you treat quality complaints?
A10: First of all, our quality control will reduce the quality problem to near zero. After production is completed, we will take samples from each batch of goods and send them to the laboratory for inspection. After passing the inspection, we will arrange delivery. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q11. How do you get the latest price of a product?
A11: Please provide accurate or approximate quantity, packaging details, destination port, or special requirements, and then we can give you the corresponding price.
Q12. How to contact us?
A12: You can chat with us via WhatsApp, Skype, Zalo, WeChat, and QQ.
You can choose the products you are interested in and send an inquiry to us.
You can dial our telephone directly or send an Email to us. You will get our reply.
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